Answer
In Zestoretic, lisinopril inhibits ACE, reducing angiotensin II, vasopressor activity and aldosterone secretion, while hydrochlorothiazide increases renal sodium and chloride excretion; their complementary actions have an additive blood-pressure-lowering effect, although the mechanism of thiazides’ antihypertensive effect is unknown.
Sources for this answer
- Zestoretic 20Atnahs Pharma UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 23Document updated
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