Answer
St John's wort can induce CYP3A4 and/or P-glycoprotein, potentially reducing plasma concentrations of Ryeqo's relugolix component and decreasing therapeutic effects, so concomitant use is not recommended.
Sources for this answer
- Ryeqo 40mg/1mg/0.5mg film-coated tabletsGedeon Richter (UK) Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 6Document updated
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