Answer
Clarithromycin may significantly increase exposure to the amlodipine component of Exforge (amlodipine + valsartan), with potentially more pronounced clinical effects in elderly patients, so clinical monitoring and dose adjustment may be required.
Sources for this answer
- Exforge 5mg/80mg, 5mg/160mg, 10mg/160mg film coated tabletsNovartis Pharmaceuticals UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 24Document updated
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