Answer
Cimetidine can interfere with renal elimination of Janumet’s metformin component, increasing systemic exposure and potentially lactic acidosis risk; benefits and risks should be considered, along with close blood glucose monitoring, dose adjustment within recommended dosing and changes in diabetes treatment.
Sources for this answer
- Janumet 50 mg/1000 mg film-coated tabletsMerck Sharp & Dohme (UK) Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 26Document updated
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