Metformin · Medicine question

How can cimetidine affect metformin levels in the blood?

iatroX medicinesPublished 8 November 2026

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Cimetidine inhibits OCT2 and may reduce metformin elimination by the kidneys, increasing its blood concentration; caution is advised, especially with renal impairment, and metformin dose adjustment may be considered if needed.

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Glucophage 500 mg and 850 mg film coated tabletsMerck · emc · SmPC §4.5 Interaction with other medicinal products · Version 25Document updated 22 December 2025

Sources checked 8 November 2026

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