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Medicines MetforminQuestion & answer

Metformin · Medicine question

Does metformin cross the placenta during pregnancy?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Yes, metformin crosses the placenta during pregnancy, reaching levels that can be as high as maternal concentrations.

Sources for this answer

Glucophage 500 mg and 850 mg film coated tabletsMerck · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 25Document updated 22 December 2025

Sources checked 8 November 2026

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Metformin

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