Answer
Melphalan hydrochloride has limited blood–brain barrier penetration: several investigators found no measurable drug in cerebrospinal fluid, although one high-dose study in children found concentrations approximately 10% of plasma levels.
Sources for this answer
- Melphalan 50 mg Powder and Solvent for Solution for Injection/InfusionAspen · emc · SmPC §5.2 Pharmacokinetic properties · Version 8Document updated
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