aprotinin + calcium chloride + human fibrinogen + human thrombin · Medicine question

Can TISSEEL be used in someone allergic to cattle proteins?

Name: Can TISSEEL be used in someone allergic to cattle proteins?
Published: 2026-08-18T17:36:39.286Z

iatroX medicinesPublished 18 August 2026Reviewed 18 August 2026

The answer

Answer

Synthetic aprotinin is structurally identical to bovine aprotinin, so use in a person with bovine-protein allergy requires careful specialist evaluation.

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TISSEEL Ready to use Solutions for Sealantemc · SmPC Current selected SmPC · Version 7

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