Answer
Standard hard capsules should be swallowed whole. Gastro-resistant capsules must not be opened or chewed because this destroys their delayed-release function.
Sources for this answer
- Sodium Bicarbonate 500 mg Capsules — Current selected SmPCemc · Summary of Product Characteristics
- Nephrotrans 500mg gastro-resistant capsules — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.