Can prolonged treatment with Depo-Medrone (methylprednisolone acetate) suppress adrenal gland function?

Yes, prolonged treatment with pharmacologic doses of Depo-Medrone (methylprednisolone acetate) may suppress the hypothalamic-pituitary-adrenal axis, causing secondary adrenal insufficiency that can persist for months after stopping treatment, and abrupt withdrawal can cause fatal acute adrenal insufficiency.