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Medicines GlucarpidaseQuestion & answer

Glucarpidase · Medicine question

Can methotrexate concentrations rise again?

iatroX medicinesPublished 17 August 2026Reviewed 17 August 2026

The answer

Answer

Yes. Rebound can occur through redistribution from tissues, so continued blood testing and folinic acid rescue may be needed.

Sources for this answer

Voraxazeemc · SmPC Current selected SmPC · Version 1
PubMedPubMed · Reputable Web

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More questions about Glucarpidase

Is glucarpidase chemotherapy?Does it remove methotrexate from inside cells?Does it replace folinic acid rescue?Can it reverse methotrexate-related kidney damage?Why are methotrexate levels checked afterwards?Why can immunoassay results be misleading?

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Glucarpidase

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