Answer
Yes, although rectal treatment is intended to reduce systemic exposure. Risk is more relevant with extensive or prolonged use or with products that increase prednisolone exposure.
Sources for this answer
- Prednisolone 20 mg/dose Rectal Foam — Current selected SmPCemc · Summary of Product Characteristics
- Prednisolone 20 mg/100 ml Rectal Solution — Current selected SmPCemc · Summary of Product Characteristics