trabectedin · Medicine question

Why should trabectedin not be used during pregnancy?

iatroX medicinesPublished 8 November 2026

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Trabectedin should not be used during pregnancy because its known mechanism of action suggests it may cause serious birth defects, although sufficient clinical data on exposed pregnancies are unavailable.

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Yondelis 0.25 mg powder for concentrate for solution for infusionImmedica · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 23Document updated 1 October 2025

Sources checked 8 November 2026

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For how long is breastfeeding contraindicated during and after trabectedin treatment?What heart monitoring is recommended before and during trabectedin treatment?Can trabectedin cause rhabdomyolysis?For which adults with advanced soft tissue sarcoma is trabectedin (Yondelis) indicated?For which type of ovarian cancer is trabectedin (Yondelis) indicated in combination with pegylated liposomal doxorubicin?How much potassium and sucrose does each vial of Yondelis 0.25 mg trabectedin powder for concentrate for solution for infusion contain?

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