Answer
St John's wort should be avoided with Koselugo because it is a strong CYP3A4 inducer that may decrease plasma concentrations of selumetinib, Koselugo’s active substance.
Sources for this answer
- Koselugo 10 mg hard capsulesAstraZeneca UK Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 8Document updated
Sources checked