Answer
Rifampicin should not be combined with nilotinib because it potently induces CYP3A4, reducing nilotinib peak concentration by 64% and overall exposure (AUC) by 80%; interaction studies were performed only in adults.
Sources for this answer
- Tasigna 50mg, 150mg and 200 mg hard capsulesNovartis Pharmaceuticals UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 39Document updated
Sources checked