Answer
Rifampicin should be avoided with Akynzeo capsules because it induces CYP3A4 and reduces netupitant exposure, decreasing its AUC 5.2-fold and peak concentration 2.6-fold.
Sources for this answer
- Akynzeo 300mg/0.5mg hard capsulesChugai Pharma UK Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 7Document updated
Sources checked