Answer
Ribavirin may disrupt azathioprine metabolism, causing 6-MTIMP accumulation associated with myelotoxicity, so its use with peginterferon alfa-2a and azathioprine should be avoided unless benefit warrants risk, with close haematologic monitoring and treatment stopped if myelotoxicity appears.
Sources for this answer
- Ribavirin 200 mg film-coated tabletsAurobindo Pharma - Milpharm Ltd. · emc · SmPC §4.5 Interaction with other medicinal products · Version 9Document updated
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