Answer
Prolonged ropivacaine hydrochloride administration should be avoided with fluvoxamine or enoxacin because these strong CYP1A2 inhibitors can interfere with its metabolism; fluvoxamine reduced ropivacaine plasma clearance by up to 77%.
Sources for this answer
- Ropivacaine Hydrochloride 2 mg/ml solution for injection/infusionB.Braun Medical · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated
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