Answer
Abrupt withdrawal in Parkinson’s disease can cause severe rigidity, fever and confusion. Reduction can also cause anxiety, depression, apathy, sweating, fatigue or pain, so it should be supervised.
Sources for this answer
- Pramipexole 0.18mg Tablets — Current selected SmPCemc · Summary of Product Characteristics
- Pipexus prolonged-release tablets — Current selected SmPCemc · Summary of Product Characteristics