Answer
Melatonin and fluvoxamine should be avoided together in adults because fluvoxamine inhibits melatonin metabolism through CYP1A2 and CYP2C19, increasing melatonin exposure 17-fold (AUC) and peak serum concentration 12-fold.
Sources for this answer
- CircadinFlynn Pharma Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 12Document updated
Sources checked