Answer
Itraconazole should be avoided with Ogsiveo because it strongly inhibits CYP3A4 and inhibits P-glycoprotein, increasing nirogacestat peak concentration (Cmax) 2.5-fold and overall exposure (AUC) 8.2-fold in a clinical study.
Sources for this answer
- Ogsiveo 150 mg film coated tabletsMerck · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated
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