Answer
Concomitant tucatinib and gemfibrozil should be avoided because gemfibrozil, a strong CYP2C8 inhibitor, increases tucatinib concentrations and may increase the risk of tucatinib toxicity.
Sources for this answer
- TUKYSA 50 mg film-coated tabletPfizer Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 5Document updated
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