Answer
Concomitant use of trastuzumab emtansine and clarithromycin should be avoided because clarithromycin strongly inhibits CYP3A4, potentially increasing exposure to DM1, a component of trastuzumab emtansine, and its toxicity.
Sources for this answer
- Kadcyla 100 mg and 160 mg Powder for Concentrate for Solution for InfusionRoche Products Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 18Document updated
Sources checked