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Medicines benzocaineQuestion & answer

benzocaine · Medicine question

Why should benzocaine not be used with sulphonamides?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Benzocaine inhibits the actions of sulphonamides and therefore should not be used concomitantly with any sulphonamide.

Sources for this answer

Orajel Mouth GelChurch & Dwight UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 2Document updated 30 April 2015

Sources checked 8 November 2026

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benzocaine

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Can Orajel Mouth Gel containing benzocaine be used by people with a family history of methaemoglobinaemia?How does benzocaine produce local numbness?How should the affected area be prepared before applying Orajel Mouth Gel containing benzocaine?Through which tissues is benzocaine rapidly absorbed?What evidence is available about the safety of benzocaine during pregnancy?Where and how is benzocaine broken down in the body?

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