Answer
Pethidine must not be given with isocarboxazid because this monoamine oxidase inhibitor combination can cause serious, potentially fatal reactions, including central excitation, muscle rigidity, hyperpyrexia, circulatory collapse, respiratory depression and coma.
Sources for this answer
- Isocarboxazid Tablets 10mgAlliance Pharmaceuticals · emc · SmPC §4.5 Interaction with other medicinal products · Version 10Document updated
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