Answer
Omeprazole must not be used with nelfinavir because it lowers nelfinavir exposure: omeprazole 40 mg once daily reduced mean nelfinavir exposure by approximately 40% and exposure to its pharmacologically active metabolite M8 by approximately 75–90%.
Sources for this answer
- Losec Capsules 40mgNeon Healthcare Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 24Document updated
Sources checked