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Medicines carbidopa monohydrate + levodopaQuestion & answer

carbidopa monohydrate + levodopa · Medicine question

Why must it not be stopped suddenly?

iatroX medicinesPublished 19 August 2026Reviewed 19 August 2026

The answer

Answer

Abrupt withdrawal can cause severe worsening and a potentially dangerous syndrome involving stiffness, high temperature and mental change.

Sources for this answer

Duodopa intestinal gelemc · SmPC Current selected SmPC · Version 22
Carbidopa/Levodopa Orion 12.5 mg/50 mg tabletsemc · SmPC Current selected SmPC · Version 3

Lecado 100/25 mg Modified-release Tablets

emc · SmPC Current selected SmPC · Version 11

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The full medicine guide

carbidopa monohydrate + levodopa

Read the wider context, including uses, precautions and the sources behind this medicine guide.

Read the carbidopa monohydrate + levodopa guide

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More questions about carbidopa monohydrate + levodopa

Is carbidopa monohydrate + levodopa the same as co-careldopa?Can it cause sudden sleep?Can it change behaviour or urges?Can it darken urine or saliva?How does Duodopa differ from tablets?