Answer
Darifenacin hydrobromide must not be taken with ketoconazole because ketoconazole potently inhibits CYP3A4, an enzyme involved in darifenacin metabolism, and can substantially increase darifenacin exposure.
Sources for this answer
- Emselex 7.5mg prolonged-release tabletspharmaand GmbH · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated
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