Answer
Anakinra (Kineret) may normalize CYP450 enzyme formation suppressed by chronic inflammation, so starting or stopping it may warrant monitoring the effect or concentration of narrow-therapeutic-index medicines such as warfarin or phenytoin and adjusting their doses.
Sources for this answer
- Kineret 100 mg solution for injection in a pre-filled syringeSwedish Orphan Biovitrum Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 20Document updated
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