Answer
Voriconazole is contraindicated with efavirenz/emtricitabine/tenofovir disoproxil maleate because efavirenz significantly lowers voriconazole plasma concentrations, voriconazole significantly raises efavirenz plasma concentrations, and the fixed-dose combination prevents adjustment of the efavirenz dose.
Sources for this answer
- Efavirenz/Emtricitabine/Tenofovir Disoproxil Mylan 600 mg/200 mg/245 mg Film-coated TabletsViatris (formerly Mylan or Upjohn) · emc · SmPC §4.3 Contraindications · Version 16Document updated
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