sirolimus · Medicine question

Why is taking sirolimus with clarithromycin not recommended?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Taking sirolimus with clarithromycin is not recommended because clarithromycin strongly inhibits CYP3A4 and/or P-glycoprotein, which may increase sirolimus blood levels.

Sources for this answer

Rapamune 2 mg coated tabletsPfizer Limited · emc · SmPC §4.4 Special warnings and precautions for use · Version 54Document updated 21 August 2024

Sources checked 8 November 2026

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