Answer
Taking siponimod fumaric acid with fluconazole is not recommended because fluconazole moderately inhibits CYP2C9 and CYP3A4, causing a clinically relevant increase in siponimod exposure.
Sources for this answer
- Mayzent 0.25 mg, 1 mg & 2 mg film-coated tabletsNovartis Pharmaceuticals UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 10Document updated
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