Answer
Taking phenytoin with thiotepa is not recommended because reduced digestive absorption of phenytoin may worsen convulsions, while phenytoin-induced increases in hepatic metabolism may enhance thiotepa toxicity and reduce its efficacy.
Sources for this answer
- Thiotepa Riemser 15 mg powder for concentrate for solution for infusionEsteve Pharmaceuticals (formerly Intrapharm Laboratories) · emc · SmPC §4.5 Interaction with other medicinal products · Version 2Document updated
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