Answer
Taking fezolinetant with fluvoxamine is contraindicated because fluvoxamine strongly inhibits CYP1A2, increasing fezolinetant peak concentration (Cmax) 1.8-fold and overall exposure (AUC) 9.4-fold, raising clinical concern.
Sources for this answer
- Veoza 45 mg film-coated tabletsAstellas Pharma Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 5Document updated
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