tadalafil · Medicine question

Why is tadalafil contraindicated with riociguat?

iatroX medicinesPublished 8 November 2026

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Answer

Tadalafil is contraindicated with riociguat because riociguat increases the blood-pressure-lowering effects of PDE5 inhibitors such as tadalafil, and the combination showed no evidence of favourable clinical benefit in the population studied.

Sources for this answer

Cialis 2.5mg film-coated tabletsEli Lilly and Company Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 33Document updated 24 February 2026

Sources checked 8 November 2026

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