Why is systemic absorption of fluticasone propionate from Flixonase Aqueous Nasal Spray negligible?

Systemic absorption of fluticasone propionate from Flixonase Aqueous Nasal Spray is negligible because low aqueous solubility limits direct nasal absorption, most of the dose is swallowed, and poor gastrointestinal absorption plus pre-systemic metabolism limit oral systemic exposure to less than 1%.