Answer
St John's Wort is contraindicated with irinotecan because it decreases plasma concentrations of irinotecan’s active metabolite, SN-38; a small study involving five patients observed a 42% decrease.
Sources for this answer
- Campto 20mg/ml concentrate for solution for infusion (40mg presentation)Pfizer Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 27Document updated
Sources checked