Answer
St John's wort is a strong CYP3A inducer expected to reduce plasma concentrations of darunavir, ritonavir and cobicistat, potentially causing loss of therapeutic effect and development of resistance.
Sources for this answer
- Darunavir Mylan 800 mg Film-coated TabletsViatris (formerly Mylan or Upjohn) · emc · SmPC §4.3 Contraindications · Version 7Document updated
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