Answer
Rifinah (isoniazid + rifampicin) is contraindicated with lurasidone because rifampicin induces CYP3A4, markedly reducing lurasidone exposure and likely its therapeutic effectiveness; rifampicin 600 mg reduced lurasidone AUC by 81%.
Sources for this answer
- Rifinah 150mg/100mg TabletsSANOFI · emc · SmPC §4.5 Interaction with other medicinal products · Version 26Document updated
Sources checked