Answer
Rifampicin is not recommended with raltegravir 1,200 mg once daily because, although its impact on this regimen is unknown, its strong induction of UGT1A1 is likely to decrease raltegravir trough levels, based on findings with 400 mg twice daily.
Sources for this answer
- Raltegravir 600 mg film-coated tabletsLupin Healthcare (UK) Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated
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