Answer
Rifampicin is contraindicated with darunavir boosted with ritonavir or cobicistat because its strong CYP3A induction is expected to reduce their plasma concentrations, potentially causing loss of therapeutic effect and development of resistance.
Sources for this answer
- Darunavir 800 mg Film-Coated TabletsDr. Reddy's Laboratories (UK) Ltd · emc · SmPC §4.3 Contraindications · Version 4Document updated
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