Answer
RAS mutations can keep growth signalling active despite EGFR blockade. Cetuximab should not be used for colorectal cancer with mutated or unknown RAS status.
Sources for this answer
- Erbitux 5mg/ml solution for infusion — Current selected SmPCemc · Summary of Product Characteristics
- UK GovernmentUK Government · Reputable Web
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.