paroxetine · Medicine question

Why is paroxetine contraindicated with pimozide?

iatroX medicinesPublished 8 November 2026

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Answer

Paroxetine is contraindicated with pimozide because it can increase pimozide levels, and pimozide has a narrow therapeutic index and can prolong the QT interval.

Sources for this answer

Paroxetine 30 mg TabletsSandoz Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 14Document updated 17 April 2024

Sources checked 8 November 2026

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