Answer
Some mitochondrial mutations increase susceptibility to aminoglycoside-related hearing damage. Tell the prescriber about a known mutation or maternal family history of deafness.
Sources for this answer
- Gentisone HC Ear Drops/ Gentamicin 0.3% w/v and Hydrocortisone acetate 1% w/v Ear Drops — Current selected SmPCemc · Summary of Product Characteristics
- UK Government