Answer
Ifosfamide metabolites can irritate and cause bleeding in the bladder lining. Mesna binds harmful urinary metabolites and is used with hydration and urine monitoring to reduce this risk.
Sources for this answer
- Ifosfamide Injection 2g — Current selected SmPCemc · Summary of Product Characteristics
- NHSNHS · NHS medicine guidance
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.