Answer
Lithium is not recommended with olmesartan medoxomil/hydrochlorothiazide because reversible serum lithium increases and toxicity have been reported rarely with angiotensin II receptor antagonists, while thiazides reduce renal lithium clearance, potentially increasing toxicity risk; if the combination is necessary, careful serum lithium monitoring is recommended.
Sources for this answer
- Olmesartan/Hydrochlorothiazide 20 mg/12.5 mg film-coated tabletsThornton & Ross Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 2Document updated
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