Answer
Pentostatin is cleared mainly through the kidneys. Reduced kidney function can prolong exposure, and the UK product is contraindicated below its specified creatinine-clearance threshold.
Sources for this answer
- Nipent 10 mg powder for solution for injection, powder for solution for infusion — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.