Answer
Systemic cefuroxime is mainly cleared by the kidneys. Reduced clearance can increase exposure and the risk of neurological toxicity.
Sources for this answer
- Cefuroxime 1.5 g powder for solution for injection/infusion — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.