Answer
Both components are cleared mainly through the kidneys, so impaired or changing renal function can increase exposure and requires prescribing review.
Sources for this answer
- Zerbaxa 1 g/0.5 g powder for concentrate for solution for infusion — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.