Answer
Ketoconazole is contraindicated with cariprazine hydrochloride because strong CYP3A4 inhibition doubled total cariprazine exposure during four days of co-administration, with further increases expected during longer use because its active components have long half-lives.
Sources for this answer
- Reagila 1.5 mg 3 mg 4.5 mg 6 mg hard capsulesGedeon Richter (UK) Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 7Document updated
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